bx 795 Search Results


bx 795  (Tocris)
93
Tocris bx 795
Bx 795, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bx 795/product/Tocris
Average 93 stars, based on 1 article reviews
bx 795 - by Bioz Stars, 2026-05
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tbk1 inhibitor  (Selleck Chemicals)
95
Selleck Chemicals tbk1 inhibitor
Tbk1 Inhibitor, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
tbk1 inhibitor - by Bioz Stars, 2026-05
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bx 795  (Santa Cruz Biotechnology)
90
Santa Cruz Biotechnology bx 795
Bx 795, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
bx 795 - by Bioz Stars, 2026-05
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tbk1 inhibitor bx795  (Tocris)
93
Tocris tbk1 inhibitor bx795
The Stimulator of Interferon Genes (STING) pathway is activated in Hut78 by 8–MOP + UVA treatment. Downregulation of alleged pathway elements by specific small interfering RNA (siRNA) or by a chemical inhibitor result in decreased IFNL1 expression. Expression of IFNL1 following 8–MOP + UVA treatment combined with ( A ) STING downregulation by siRNA, ( B ) cyclic GMP-AMP synthase (cGAS) downregulation by siRNA, ( C ) <t>TBK1</t> inhibition by <t>BX795</t> chemical inhibitor, ( D ) IRF3 downregulation by siRNA and ( E ) IRF1 downregulation by siRNA. Cell viability for respective treatments is presented in ( F ) for STING-siRNA, ( G ) for cGAS-siRNA, ( H ) for BX795-mediated TBK1 inhibition, ( I ) for IRF3-siRNA and ( J ) for IRF1-siRNA. ( K ) Transfection efficiencies for various siRNAs. Error bars represent ± SEM of the indicated N repeats. Statistics—normal distribution, paired t -test: ( A – E ) and skewed distribution, paired Wilcoxon: (F–J) . Choice of the statistical test was made based on the type of data distribution (see Methods). * p < 0.1, ** p < 0.05, ns–not significant.
Tbk1 Inhibitor Bx795, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tbk1 inhibitor bx795/product/Tocris
Average 93 stars, based on 1 article reviews
tbk1 inhibitor bx795 - by Bioz Stars, 2026-05
93/100 stars
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bx795 #14932  (Cayman Chemical)
90
Cayman Chemical bx795 #14932
IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with <t>BX795</t> for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.
Bx795 #14932, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bx795 #14932/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
bx795 #14932 - by Bioz Stars, 2026-05
90/100 stars
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bx-795  (Gallus BioPharmaceuticals)
90
Gallus BioPharmaceuticals bx-795
IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with <t>BX795</t> for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.
Bx 795, supplied by Gallus BioPharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bx-795/product/Gallus BioPharmaceuticals
Average 90 stars, based on 1 article reviews
bx-795 - by Bioz Stars, 2026-05
90/100 stars
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bx-795  (Adooq Bioscience LLC)
90
Adooq Bioscience LLC bx-795
IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with <t>BX795</t> for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.
Bx 795, supplied by Adooq Bioscience LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bx-795/product/Adooq Bioscience LLC
Average 90 stars, based on 1 article reviews
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bx-795  (Merck KGaA)
90
Merck KGaA bx-795
IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with <t>BX795</t> for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.
Bx 795, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bx-795/product/Merck KGaA
Average 90 stars, based on 1 article reviews
bx-795 - by Bioz Stars, 2026-05
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tank binding kinase 1 (tbk1)/i, kappa b kinase (ikk)ε inhibitor bx-795  (Biomol GmbH)
90
Biomol GmbH tank binding kinase 1 (tbk1)/i, kappa b kinase (ikk)ε inhibitor bx-795
IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with <t>BX795</t> for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.
Tank Binding Kinase 1 (Tbk1)/I, Kappa B Kinase (Ikk)ε Inhibitor Bx 795, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tank binding kinase 1 (tbk1)/i, kappa b kinase (ikk)ε inhibitor bx-795 - by Bioz Stars, 2026-05
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bx 795  (Cayman Chemical)
N/A
BX 795
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bx-795  (LKT Laboratories)
N/A
PDK1 inhibitor.
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bx-795  (BOC Sciences)
N/A
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with
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The Stimulator of Interferon Genes (STING) pathway is activated in Hut78 by 8–MOP + UVA treatment. Downregulation of alleged pathway elements by specific small interfering RNA (siRNA) or by a chemical inhibitor result in decreased IFNL1 expression. Expression of IFNL1 following 8–MOP + UVA treatment combined with ( A ) STING downregulation by siRNA, ( B ) cyclic GMP-AMP synthase (cGAS) downregulation by siRNA, ( C ) TBK1 inhibition by BX795 chemical inhibitor, ( D ) IRF3 downregulation by siRNA and ( E ) IRF1 downregulation by siRNA. Cell viability for respective treatments is presented in ( F ) for STING-siRNA, ( G ) for cGAS-siRNA, ( H ) for BX795-mediated TBK1 inhibition, ( I ) for IRF3-siRNA and ( J ) for IRF1-siRNA. ( K ) Transfection efficiencies for various siRNAs. Error bars represent ± SEM of the indicated N repeats. Statistics—normal distribution, paired t -test: ( A – E ) and skewed distribution, paired Wilcoxon: (F–J) . Choice of the statistical test was made based on the type of data distribution (see Methods). * p < 0.1, ** p < 0.05, ns–not significant.

Journal: Cells

Article Title: Photochemotherapy Induces Interferon Type III Expression via STING Pathway

doi: 10.3390/cells9112452

Figure Lengend Snippet: The Stimulator of Interferon Genes (STING) pathway is activated in Hut78 by 8–MOP + UVA treatment. Downregulation of alleged pathway elements by specific small interfering RNA (siRNA) or by a chemical inhibitor result in decreased IFNL1 expression. Expression of IFNL1 following 8–MOP + UVA treatment combined with ( A ) STING downregulation by siRNA, ( B ) cyclic GMP-AMP synthase (cGAS) downregulation by siRNA, ( C ) TBK1 inhibition by BX795 chemical inhibitor, ( D ) IRF3 downregulation by siRNA and ( E ) IRF1 downregulation by siRNA. Cell viability for respective treatments is presented in ( F ) for STING-siRNA, ( G ) for cGAS-siRNA, ( H ) for BX795-mediated TBK1 inhibition, ( I ) for IRF3-siRNA and ( J ) for IRF1-siRNA. ( K ) Transfection efficiencies for various siRNAs. Error bars represent ± SEM of the indicated N repeats. Statistics—normal distribution, paired t -test: ( A – E ) and skewed distribution, paired Wilcoxon: (F–J) . Choice of the statistical test was made based on the type of data distribution (see Methods). * p < 0.1, ** p < 0.05, ns–not significant.

Article Snippet: TBK1 inhibitor BX795 (Tocris, Abingdon, UK) and ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 (Selleckchem, Houston, TX, USA) were added immediately after UVA irradiation.

Techniques: Small Interfering RNA, Expressing, Inhibition, Transfection

IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with BX795 for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.

Journal: Biomolecules & Therapeutics

Article Title: Identification of Small GTPases That Phosphorylate IRF3 through TBK1 Activation Using an Active Mutant Library Screen

doi: 10.4062/biomolther.2022.119

Figure Lengend Snippet: IRF3 phosphorylation mediated by small GTPases require TBK1. (A) HEK293 cells were co-transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of GTPases, respectively. 24 h post transfection, the cells were treated with BX795 for 3 h. (B) HEK293 cells were transfected with 0.2 µg of FLAG-IRF3 and 0.2 µg of HA-RHEB-Q64L or empty plasmid. 24 h post transfection, the cells were treated with Rapamycin or vehicle for 3 h. (C) Overall scheme of this study.

Article Snippet: BX795 (#14932) was from Cayman (Ann Arbor, MI, USA).

Techniques: Phospho-proteomics, Transfection, Plasmid Preparation